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|Section2= |Section3= }} 2,6-Pyridinedicarbothioic acid (PDTC) is an organosulfur compound that is produced by some bacteria. It functions as a siderophore, a small chelating agent with a high affinity for iron. Siderophores are deployed as ion scavengers for microbes. Siderophores solubilize compounds by forming strong complexes. PDTC is secreted by the soil bacteria ''Pseudomonas stutzeri'' and ''Pseudomonas putida''. ==Synthesis and biosynthesis== PDTC can be synthesized by treating the pyridine-2,6-dicarboxylic acid (or its diacid dichloride) with H2S in dry pyridine: :NC5H3(COOH)2 + 2 H2S → NC5H3(COSH)2 + 2 H2O This produces an orange 1:1 pyridinium salt of 2,6-pyridinedicarbothioate. Treatment of this salt with acid give PDTC, which can then be extracted with dichloromethane. The biosynthesis of PDTC remains unclear although some insights can be deduced from the genetics. It is suggested that ''Pseudomonas stutzeri'' may have acquired at least one of the genes by lateral transfer from mycobacteria. In a proposed biosynthetic sequence pyridine-2,6-dicarboxylic acid, a known bacterial metabolite,〔 is activated as its bis-adenosine monophosphate (AMP) derivative. The sulfur donor and its activation remain uncertain. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「2,6-Pyridinedicarbothioic acid」の詳細全文を読む スポンサード リンク
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